APS1 (APECED), NIH: National Institute of Allergy and

2 天前APS1 (APECED) Autoimmune polyglandular syndrome type 1 (APS1), also called autoimmune polyendocrinopathycandidiasisectodermal dystrophy (APECED), is a genetic immune disorder. This disorder has a diverse range of symptoms, including autoimmunity against different organs and an increased susceptibility to candidiasis, a fungal infection

Autoimmune polyendocrinopathy candidiasis ectodermal

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene. This review focuses on the clinical and immunological features of APECED, summarizes the

APECED: is this a model for failure of T cell and B cell

In APECED, the key abnormality is in the T cell defect that may lead to tissue destruction chiefly in endocrine organs. Besides, APECED is characterized by hightiter antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED, mainly chronic mucocutaneous candidiasis, and linked to antibodies against Th17 cells effector molecules, IL

免疫调节因子 百度百科

APECED(autoimmune polyendocrinopathycandidiasisectodermal dystrophy,APECED)又称自身免疫性多腺体综合征I(autoimmune polyglandular syndronme type I,APS I)是单一基因突变而引起的自身免疫性

Cell:免疫疾病新疗法 自身免疫多内分泌腺病综合征1型

APECED患者共同生成的一些自身抗体中包括了1 型糖尿病的一种标记物,叫做 谷氨酸 脱羧酶自身抗体(GAD)。由于GAD自身抗体与形成1型糖尿病密切相关。作者们指出,令人惊讶地是只有1020%的APECED患者形成了糖尿病

Syndrome Apeced ou polyendocrinopathie autoimmune

Apeced syndrome is a rare disease, with autosomal recessive transmission and associated with mutations of the AIRE gene, which is involved in central and peripheral immune tolerance mechanisms. Its diagnosis is classically based on the combination of any two of the following three major criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and autoimmune chronic

APECED, Harvinaissairaudet.fi, Terveyskyl

2 天前APECED. Tulosta. Avainsanat: Autoimmuunipolyendokrinopatiakandidoosiektodermidystrofia, autoimmuunipolyendokrinopatia tyyppi 1, APS 1. Dgkoodi: ICD10 E31.0, ORPHA 3453. APECED on synnynninen autoimmuunisairaus, joka johtuu AIREgeenin mutaatioista. Autoimmuunisairauksissa elimist hykk omia kudoksia vastaan.

APECED – Wikipedia

APECEDtaudin oireina esiintyy jo lapsuudessa alkavia, useita elinspesifisi autoimmuunitauteja. Yleisi oireita ovat suun krooninen Candidainfektio, hypoparatyreoidismi, lismunuaisen kuorikerroksen vajaatoiminta eli Addisonin tauti, hypogonadismi, krooninen atrofinen gastriitti, diabetes ja kilpirauhasen sairaudet.

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